ORPHA Synonym(s). Bickel-Fanconi glycogenosis; Fanconi-Bickel disease; GSD due to GLUT2 deficiency; GSD type 11; GSD type XI; Glycogen storage. Fanconi-Bickel syndrome (FBS) is a rare inherited glycogen storage disease ( GSD) caused by defects in facilitative Glucose Transporter (GLUT2) gene that. NIH Rare Diseases: Fanconi Bickel syndrome (FBS) is a rare condition characterized by the accumulation of a substance called glycogen in different parts of the.

Author: Merg Samuhn
Country: Mozambique
Language: English (Spanish)
Genre: Automotive
Published (Last): 16 February 2016
Pages: 30
PDF File Size: 12.93 Mb
ePub File Size: 18.13 Mb
ISBN: 806-9-90081-135-8
Downloads: 98046
Price: Free* [*Free Regsitration Required]
Uploader: Kektilar

A bonus to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships. Chromosomal mapping of some inherited forms of proximal renal tubular acidosis[ 496970 ]. Other search option s Alphabetical list. Supplemental feeds were started 2 months back in the form of cereals and fancobi.

Among the members of the facilitative glucose transporter family, Santer et al. Brenner and Rector’s The Kidney.

Nelson text book of pediatrics. Glykogenose der Leber mit Aminoacidurie und Glucosurie: Fanconi-Bickel syndrome is a rare but well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose Manz et al.


Molecular pathophysiology of renal tubular acidosis. He had never had any medication and was consuming a great deal of milk. An 8 month old male child, product of consanguineous marriage belonging to far flung area presented with progressive abdominal distension from 3 months.

A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity. GLUT2 mutations associated with a mild phenotype. The diagnosis can be confirmed by identification of a mutation in the SLC2A2 gene. Sensitivity was increased to insulin and decreased to adrenaline. A homozygous missense mutation, SLC2A2, PROLEU, was described in a large family with a high degree of consanguinity; it showed several affected afnconi of both sexes, markedly reduced liver phosphorylase kinase activity was found in association with the characteristic clinical features and laboratory findings of FBS[ 61 ], thus suggesting that FBS is genetically heterogeneous and that there may be another subtype of PHK deficiency possibly associated with a distinctive genotype that gives rise to hepatorenal glycogenosis.


Hypoglycemia is exacerbated by renal loss of glucose due to a transport defect for glucose and galactose across the basolateral membranes of the tubular cells. Polyuria, probably due to osmotic diuresis, was a constant finding. The gene was localized to human chromosome syndgome Patients should follow a galactose-restricted diabetic diet with fructose as the main source of carbohydrate. Defective galactose oxidation in a patient with glycogen storage disease and Fanconi syndrome.

Fanconi’s syndrome with hepatorenal glycogenosis associated with phosphorylase b kinase deficiency.

Glycogen storage disease type XI

In view of rickets hepatomegaly, failure to thrive, doll like face and developmental delay, a possibility of Fanconi-Bickel disease was made and patient was extensively evaluated for the above disorder.

July 26, ; Published date: The long-term prognosis is unknown. The renal tubular acidoses.

Syndorme Upcoming Special Issues. Defects in metabolism of carbohydrates. It was speculated that mutant GLUT2 proteins may have a dominant-negative effect and that heterozygosity for a nonsense mutation may not lead to glucosuria because of selective and efficient degradation of the nonsense mRNA[ 55 ].

Please review our privacy policy. We are determined to keep this website freely accessible.


Ann Jose ankara escort. Catch-up growth in Fanconi-Bickel syndrome with uncooked cornstarch. The first was two bases deletion, guanine and adenine, c. A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity. By two years of age enlarged kidneys are noticeable clinically.

Fanconi-Bickel syndrome as an example of marked allelic heterogeneity

The GLUT5 hexose transporter is also localized to the basolateral membrane of the human jejunum. These mutations represent the first detection of a congenital defect within a whole family of membrane proteins facilitative glucose transporters.

Homozygosity or compound heterozygosity for GLUT2 mutations was found in 49 patients among these cases and 23 novel mutations of the GLUT2 gene were detected. Rickets and osteoporosis later in life were constant features.

Unfortunately, it is not free to produce. Molecular pathophysiology of tubular transport disorders. Urinary proteome pattern in children with bic,el Fanconi syndrome. Inborn errors of carbohydrate metabolism Hepatology Muscular disorders Endocrine, nutritional and metabolic disease stubs.

Glu85fs and the second is mutation in exon6 in splicing acceptor site with intron5 c. Long bone X-ray in our patient showed florid rickets.

Evaluation of renal tubular acidosis. Permeability defect with bicarbonate leak as a mechanism of immune-related distal renal tubular acidosis.

Upon renal biopsy, Manz et al. Because of failure to thrive, polydipsia, and constipation at around the age of 6 months, the patient received vitamin D and calcium supplements.