CASE REPORT. Membranoproliferative associated with type II in a renal transplant patient with hepatitis C. Glomerulonefrite membranoproliferativa em. Disease definition. Dense deposit disease, a histological subtype of MPGN (see this term) is an idiopathic chronic progressive kidney disorder distinguished by. Glomerulonefrite membranoproliferativa. Classificação Até achados estruturais e histopatológico fisiopatologia e.

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For these reasons we decided to treat the patient with this drug. Hepatitis C virus infection and de novo glomerular lesions in renal allografts.

Renal involvement in hepatitis C infection: This diagnostic was surprising since the patient presented with sustained negative viral load, but there are other reported cases in the literature of HCV-related glomerulonephritis in patients with undetectable HCV-RNA J Nephropathol ;2 4: Boceprevir for untreated chronic HCV genotype 1 infection. For all other comments, please send your remarks via contact us. He had a history glo,erulonefrite illicit drug abuse cocaine and heroin with methadone replacement therapy since Scientifica Cairo ; doi.

The association between race and histologic type was not influenced by the potential effects of age, gender and hepatosplenic schistosomiasis.

Clin J Am Soc Nephrol ;4 1: Higher HCV viral loads may result in more immune complexes and increased deposition of membranoproliferativ complexes in the kidney and a higher risk for HCV-related nephropathy 1,13 on the contrary, a sustained virological response serum HCV-RNA glomerulonefritee may reduce post-transplant recurrence of HCVas well as chronic allograft nephropathy 1,13, J Am Soc Nephrol ;7 Recurrent membranoproliferative glomerulonephritis after kidney transplantation.


The most common HCV-related nephropathy is membranoproliferatkva glomerulonephritis MPGNusually in the context of cryoglobulinaemia 6,7. The patient was lost for follow-up.

Glomerulonefrite membranoproliferativa

Hepatitis C virus-associated membranoproliferative glomerulonephritis in renal allografts. Hepatitis C infection in kidney transplantion. Como citar este artigo. Specialised Social Services Eurordis directory. The allograft biopsy showed lesions compatible with membranoproliferativewith staining in the immunofluorescence for granular IgM and C3 and no C4d.

His baseline serum creatinine SCr was 1. Kidney Int Suppl ; Treatment of hepatitis C-virus related.

Clin Transplant ;20 6: Patients with systemic lupus erythematosus or any kind of autoimmune disease were not included in the present analysis. The main goal of antiretroviral therapy before transplantation is to achieve sustained viral response, because glomeruloenfrite risk of hepatic and extra hepatic complications is reduced. Management of the kidney transplant patient with chronic hepatitis C infection.

Rituximab seems to be as least as efficient as cyclophosphamide, glomerulonnefrite also better tolerated and, in contrast to cyclophosphamide, does not enhance HCV replication7.

Orphanet: Glomerulonefrite membranoproliferativa tipo 2

After the last infusion, the patient restarted use of cocaine and was lost for follow-up. Membranoproliferative glomerulonephritis type 2 Prevalence: Hepatitis C virus antibody status and survival after renal transplantation: Hepatitis C infection and chronic renal diseases. Hepatitis C virus infection as a risk factor for graft loss after renal transplantation In: The laboratory tests revealed positive rheumatoid factor, hypocomplementaemia and a positive cryocrit with type II cryoglobulinaemia.


Crioglobulinemia; glomerulonefrite membranoproliferativa; hepatite C; rituximab; transplante renal. Ribavirin monotherapy seems to improve liver enzymes level, but is not associated with beneficial effect on liver histology neither in virological clearance. Patients from the Renal Service of the Federal University of Bahia, Brazil, 80 with focal segmental glomerulosclerosis FSG and 50 with membranoproliferative glomerulonephritis MPGN were compared regarding the distribution of the racial types black, mulatto, white.

Am J Transplant ;5 6: To date, there are no studies of this therapy in renal transplant and randomized controlled trials are needed We describe a case of membranoproliferative associated with type II in a renal transplant patient with hepatitis C. There have been several case reports and studies showing the effectiveness of Rituximab in the treatment of glomerular diseases, however, more randomized studies are needed 7,8,12,21, Int J Nephrol ; doi: Post-transplantation morbidity in renal transplant patients with hepatitis C virus HCV infection may be partially explained by the risk of de novo or recurrent HCV associated glomerulopathieswhich can lead to allograft dysfunction.

Its use is not recommended in patients with renal transplant. His maintenance immunosuppressive treatment consisted of tacrolimus AdvagrafR 5.

Additional information Further information on this disease Classification s 2 Gene s 2 Other website s 2. The treatment with Rituximab allowed an improvement in renal function.