ABSTRACT. Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plant and. Abstract: Inositol hexaphosphate (IP6) is a naturally occur- ring polyphosphorylated carbohydrate, abundantly present in many plant sources and in certain. While IP-6 is found in rice bran and other foods, there are good reasons to take an IP-6 & Inositol supplement. First, IP-6 is getter absorbed in pure form without.

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Protection against cancer by dietary IP6 and inositol.

Novel anticancer function of inositol hexaphosphate IP 6: Studies using other experimental models showed that antineoplastic properties of IP 6 were not restricted to the colon. The observed anticancer effect of inositol compounds could be mediated through several other mechanisms.

A central molecule is a phosphatidylinositol-3 kinase, which primarily phosphorylates the lipid phosphatidylinositol on the 3 position of the D- myo -inositol ring, yielding phosphatidylinositolphosphate, but also can use phosphorylated forms of phosphatidylinositol as substrates. These data indicate that the intact molecule was transported inside the gastric epithelial cells, wherein it was rapidly dephosphorylated, and that the metabolism of IP 6 was very rapid.

It was also hypothesized that the addition of inositol, a precursor of inositol phosphates and also a natural carbohydrate, to IP 6 may enhance the anticancer function of IP 6 18 — A significant reduction in the number of lung metastatic colonies by IP 6 was observed in a mouse metastatic tumor model using FSA-1 cells The most consistent and best anticancer results were obtained from the combination of IP6 plus inositol.

Adapted from Vucenik et al. Dose-dependent inhibition of large intestinal cancer by inositol hexaphosphate in F rats.

Lowering of serum cholesterol and triglycerides and modulations by dietary phytate. After subcutaneous inoculation of mouse fibrosarcoma FSA-1 cells, mice were treated with intraperitoneal injections of IP 6 and inositoll significant inhibition of tumor size and survival over untreated controls was observed. Inoaitol cancer treatment recognizes the importance of using combination therapy to increase efficacy and decrease side effects of conventional chemotherapy.


Exogenously administered IP 6 is rapidly taken up into cells and dephosphorylated to lower inositol phosphates, which further affect signal transduction pathways resulting in cell cycle arrest. A potential hypocholesterolemic effect of IP 6 may be very significant in the clinical management of hyperlipidemia and diabetes 7576 Lp6 hypothesized, it was demonstrated that IP 6 is a broad-spectrum antineoplastic agent, affecting different cells and tissue systems.

Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.

Email alerts New issue alert. It is now recognized that subsequent to PIP 2 hydrolysis a cascade of inositol phosphate metabolites are formed and that these multiple isomers show a inosutol pattern of interconversion 8 — We tested the effect of IP 6 on tumorigenicity and tumor regression in this model. Inositol phosphates and cell signalling: Inositol hexaphosphate IP 6 is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plant and mammalian cells.

Related articles in Google Scholar. IP 6 inhibits growth and reverses transformed phenotype in HepG2 human liver cancer cell line. One patient with inostiol metastasis refused chemotherapy after the first treatment, and she was treated only with IP 6 plus inosiotl her control ultrasound and abdominal computed tomography scan 14 mo after surgery showed a significantly reduced growth rate.

Inositol and inositol hexaphosphate suppress cell proliferation and tumor formation in Inpsitol mice. Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU Different binding proteins for inositol polyphosphates have been isolated, indicating their importance for the cellular functions 12 such as effects on ion channels and protein trafficking 1314endocytosis 15exocytosis 16and efficient export of mRNA from the nucleus to the cell Anticancer action of IP 6.


How can exogenously administered IP 6 affect tumor growth?

Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.

Only myo -inositol hexaphosphate has been found in plants; neo – chiro – and scyllo -inositol hexaphosphates have been isolated from soil 7. IP 6 was further shown to increase differentiation of human inositkl carcinoma HT cells 2829prostate cancer cells 33breast cancer cells 32and rhabdomyosarcoma cells From Laboratory to Clinic Ivana Vucenik.

Inositol occurs ubiquitously in cell membranes in conjugation with inositoll, as phosphatidylinositol. Contrary to the dogma and skepticism at that time, we showed that IP 6 is taken up by malignant cells 21 and that orally administered IP 6 can reach target tumor tissue distant from the gastrointestinal tract Using highly invasive MDA-MB human breast cancer cells, we demonstrated that IP 6 inhibits metastasis in vitro through effects on cancer cell adhesion, migration, and invasion 70 Oxford University Press is a department of the University of Oxford.

Derivatives of phosphatidylinositol transmit cellular signals in response to extracellular stimuli, and enzymes responsible for the phosphorylation and hydrolysis of these signaling lipids play an important role in a broad range of biological effects. Although IP 6 may belong to almost all previously mentioned categories of cancer preventive drugs, affecting almost all phases of cancer prevention, it still appears that IP 6 is not a direct antagonist to the carcinogen because of its moderate efficacy in vitro when tested and compared with other chemopreventive agents 30 and a lack of dramatic decrease in cancer incidence when tested in vivo.

IP 6 also inhibited the growth of mesenchymal tumors, murine fibrosarcoma 39and human rhabdomyosarcoma